How Much Does DSIP Cost in 2026?

DSIP (Delta Sleep-Inducing Peptide) is a short neuropeptide first identified in sleeping mammals in the 1970s. Research has examined its effects on sleep architecture, stress-hormone regulation, and circadian rhythm entrainment. In April 2026, the FDA removed DSIP from the Category 2 503A compounding list — a change that has disrupted compounding pharmacy supply while research-grade availability continues.

Current DSIP Prices by Supplier

DSIP is a relatively small peptide (9 amino acids), which typically makes synthesis more straightforward and cost-effective than larger peptides. However, post-reclassification supply dynamics are still settling.

Available Sizes

Prices sourced from publicly available supplier listings, May 2026. Verify current pricing directly with each supplier before ordering.

What Is DSIP?

DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide — a chain of just 9 amino acids (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) — originally isolated in 1977 from the cerebral venous blood of sleeping rabbits. The name reflects the original experimental observation that injecting it into waking rabbits appeared to induce delta-wave sleep patterns.

Unlike many research peptides, DSIP has been studied since the late 1970s, giving it a longer research history than most compounds on the Category 2 list. Its mechanism of action is not fully understood; research has examined multiple potential pathways including glucocorticoid regulation, ACTH release modulation, and direct effects on sleep-active brain regions.

What Researchers Study DSIP For

• Sleep regulation — DSIP was initially characterized by its ability to promote slow-wave (delta) sleep in animal models. Research has examined whether it affects sleep architecture, sleep onset, and sleep quality.
• Stress response and cortisol modulation — Studies have examined DSIP's effects on the hypothalamic-pituitary-adrenal (HPA) axis, particularly on ACTH and cortisol levels under stress conditions.
• Circadian rhythm entrainment — Some research has explored DSIP's potential role in resetting disrupted circadian rhythms, with interest in jet lag and shift-work models.
• Opiate withdrawal models — Animal studies have examined whether DSIP administration reduces symptoms in opiate withdrawal models, possibly through opioid receptor interactions.
• Antioxidant effects — Some laboratory studies have reported antioxidant properties, though the mechanism and magnitude are not well characterized.

DSIP and the April 2026 FDA Reclassification

DSIP had been on the FDA's Category 2 503A bulk drug substances list, which allowed compounding pharmacies to prepare it for patients under a physician's order. The FDA's April 23, 2026 removal of DSIP from this list means compounding pharmacies can no longer legally do so.

This primarily affects patients who were receiving DSIP through a 503A compounding pharmacy. Research suppliers continue to offer DSIP for laboratory research purposes under separate regulatory frameworks. The July 2026 PCAC meeting may clarify the path toward Category 1 listing if additional clinical evidence is submitted.

See the full FDA Peptide Reclassification 2026 guide for details on all 12 affected peptides.

Notable Research Suppliers (2026)

What to Look for in a DSIP Supplier

• Third-party COAs — DSIP should come with HPLC purity data (≥98%) from an independent, named laboratory.
• Sequence verification — Because DSIP has a specific 9-amino-acid sequence, mass spectrometry data confirming the correct molecular weight is important for research integrity.
• Lyophilized powder — DSIP should be supplied freeze-dried. Pre-dissolved solutions are less stable and more susceptible to degradation.
• Storage guidance — Reputable suppliers provide clear cold-storage instructions; DSIP should be kept at −20°C for long-term stability.

Frequently Asked Questions